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74

抑制剂 & 化合物

11

天然产物

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Cat. No. Product Name Target Signaling Pathways
T38359 Dup-721

Antibacterial Microbiology/Virology
DuP-721 是广谱的口服有效的抗菌剂,可以抑制多种临床敏感和耐药细菌,特别是结核杆菌M. tuberculosis
T8411 C-215

Others Others
C-215 是MmpL3抑制剂。它在 HTS 中被鉴定为对结核分枝杆菌具有独立的甘油活性,对哺乳动物细胞的非特异性毒性较低,对结核分枝杆菌的IC90=16 μM,并且能够有效抑制在巨噬细胞中生长的结核分枝杆菌。
T16339 Norverapamil hydrochloride

(±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Calcium Channel; P-gp; Drug Metabolite Membrane transporter/Ion channel; Metabolism; Neuroscience
Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物,是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T5400 Q203

IAP6,Telacebec

Antibacterial; Antibiotic Microbiology/Virology
Q203 (Telacebec)是一种中氮杂吡啶酰胺。 在培养基中抑制结核分枝杆菌H37Rv 活性的MIC50值为2.7 nM。
T9830 GSK2556286

GSK286

Antibacterial Microbiology/Virology
GSK2556286 (GSK286) 是一种具有口服活性的结核分枝杆菌 (M. tuberculosis) 抑制剂。GSK2556286 对人巨噬细胞 (macrophages) 生长具有抑制作用,IC50值为 0.07 μM。GSK2556286对多重耐药 (MDR) 或广泛耐药 (XDR) 和药物敏感 (DS) 结核分枝杆菌均有效。
T25817 Mitonafide

NSC-300288,米托萘胺,NSC300288,NSC 300288

Antibacterial Microbiology/Virology
Mitonafide (NSC-300288) 抑制 M. tuberculosis NAD+ 依赖性 DNA 连接酶 A 的活性。 它是一种 DNA 嵌入剂。
T5997 TBAJ-587

Antibacterial; Antibiotic Microbiology/Virology
TBAJ-587 是一种抗结核药物,在 MABA 和 LORA 试验中抑制 M.tb 菌株 H37Rv 的生长,MIC90 分别为 0.006 和 <0.02 µg/mL。它对 M. tuberculosis 具有更有效的活性,并且在 TB 动物模型中具有更好的功效。
T7312 AX20017

Others; Antibacterial Microbiology/Virology; Others
AX20017是蛋白激酶G 的一个小分子抑制剂,IC50值为 0.39 μM。
T7342 BM212

Antibacterial Microbiology/Virology
BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌,抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。
T0020 Sodium 4-aminosalicylate dihydrate

对氨基水杨酸钠二水合物,Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt

Free radical scavengers; NF-κB; Antibacterial; Antibiotic Microbiology/Virology; NF-κB; oxidation-reduction
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) 是一种抗耐药性结核化合物。
T27482 GSK572A

Others Others
GSK572A 是一种新型且强效的EchA6强效抑制剂,可用来治疗肺结核。
T4531 GSK2200150A

Antibacterial Microbiology/Virology
GSK2200150A 是一种通过高通量筛选活动确定的抗结核剂,对 H37Rv 的 MIC 是 0.38 μM。
T10563 BM635

Others Others
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T60446 LCS3

Apoptosis; Glutathione reductase Apoptosis; oxidation-reduction
LCS3是一种可逆和非竞争性的谷胱甘肽二硫化物还原酶(GSR)和硫氧还蛋白还原酶1(TXNRD1)的协同抑制剂,IC50分别为3.3μM 和3.8μM。LCS3具有抗肿瘤活性,可诱导细胞凋亡,可用于研究肺腺癌(LUAD)。
T10563L2 BM635 mesylate (1493762-74-5 free base)

BM635 mesylate

Others Others
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10563L BM635 hydrochloride (1493762-74-5 free base)

BM635 hydrochloride

Others Others
BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T39693 Polyketide synthase 13-IN-3

Polyketide synthase 13-IN-3 (compound 41) is a potent inhibitor of polyketide synthase 13, demonstrating a minimum inhibitory concentration (MIC) range of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.
T75168 Homo-BacPROTAC7

Homo-BacPROTAC7 是一个 ClpC1NTDBacPROTAC 降解剂,可以靶向 ClpC2。Homo-BacPROTAC7 能有效杀死 M. tuberculosis
T27206 DprE1-IN-377790

DprE1-IN-377790 is a novel DprE1 inhibitor, killing M. tuberculosis.
T38773 LeuRS-IN-1 hydrochloride

LeuRS-IN-1 hydrochloride is a potent and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS). It has IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively, for M.tb LeuRS. Additionally, LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS with an IC 50 of 38.8 μM and HepG2 protein synthesis with an EC 50 of 19.6 μM.
T29505 A039

A-039,A 039

A039 is a highly active bactericidal agent against M. tuberculosis.
T68809 Trichomonacid

Trichomonacid is a novel inhibitor of Mycobacterium marinum MelF (Rv1936), exhibiting bacteriostatic/bactericidal activity against M. marinum and M. tuberculosis in vitro.
T10887 CRS400393

Antibacterial Microbiology/Virology
CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively.
T39109 ML338

ML338

ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 values of 1 μM and 4 μM, respectively, as determined by CFU. This compound, ML338, is an invaluable tool for identifying essential functions and vulnerabilities of M. tuberculosis bacilli under nutrient deprivation conditions. Additionally, ML338 is highly useful for studying M. tuber...
T61573 MtTMPK-IN-5

MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, as evidenced by a minimum inhibitory concentration (MIC) of 12.5 μM. Given its potent properties, MtTMPK-IN-5 serves as a valuable tool for tuberculosis research [1].
T69488 CB5255829

CB5255829 is a novel inhibitor of Mycobacterium marinum MelF (Rv1936), exhibiting bacteriostatic/bactericidal activity against M. marinum and M. tuberculosis in vitro.
T71846 CB6513745

CB6513745 is a novel inhibitor of Mycobacterium marinum MelF (Rv1936), exhibiting bacteriostatic/bactericidal activity against M. marinum and M. tuberculosis in vitro.
T63755 Antitubercular agent-22

Antitubercular agent-22 (Compound 2) 是有效的抗念珠菌和抗结核剂,能够作用于 Candida albicansMTCC 3017 (MIC: 2.34 μg/ml) 和 M. tuberculosis(H37Rv) (MIC: 2 μg/ml)。
T61781 MtTMPK-IN-6

MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T75167 Homo-BacPROTAC6

Homo-BacPROTAC6 是一个 ClpC1NTDBacPROTAC 降解剂,可以靶向 ClpC2。Homo-BacPROTAC7 能有效杀死M. tuberculosis
T61303 MmpL3-IN-1

MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].
T61520 Antitubercular agent-24

Antitubercular agent-24 (Compound 1) exhibits anti-tubercular properties against M. tuberculosis H37Rv. It demonstrates an extracellular IC50 of 0.83 μM and an intracellular IC50 of 0.17 μM [1].
T63525 Antitubercular agent-23

Antitubercular agent-23 是有效的抗念珠菌及抗结核剂,能够作用于 Candida albicansMTCC 3017 (MIC: 1.1 μg/ml) 和 M. tuberculosis(H37Rv) (MIC: 1 μg/ml)。
T40317 α/β-Hydrolase-IN-1

α/β-Hydrolase-IN-1 demonstrates exceptional potency, with MICs of 50 μM (25 μg/mL) against M. smegmatis and 16 μM (8.4 μg/mL) against M. tuberculosis H37Ra, establishing it as a superior compound in this class.
T28480 Q-203 Ditosylate

Q203,Q-203,Q 203

Q-203 Ditosylate, also known as Q-203, is a mycobacterium tuberculosis protein potentially for the treatment of tuberculosis. The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in
T71449 Capreomycin free base

Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 µg/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis.
T38355 Lariatin A

Lariatin A is an antimycobacterial lasso peptide originally isolated from R. jostii. It is active against M. tuberculosis and M. smegmatis in vitro (MICs = 0.39 and 0.1 μg/ml, respectively). Lariatin A increases survival in a silkworm model of M. smegmatis infection (ED50 = 0.5 μg/g).
T61170 Antibacterial agent 96

Antibacterial agent 96 (compound 4k) 是一种有效的抗菌剂。Antibacterial agent 96 对药物敏感和耐多药的结核分枝杆菌 (M.tuberculosis)显示出抗结核活性。Antibacterial agent 96 对 HepG2 和 Vero 细胞有毒性。
T63786 WX-081

WX-081 是抗结核剂 (anti-tuberculosis),对 M. tuberculosisH37Rv 表现出明显的抗分枝杆菌效果,并能够作用于药物敏感结核病 (DS-TB) 杆菌 (MIC: 0.083 μg/ml) 和耐多药结核病 (MDR-TB) 菌株 (MIC: 0.11 μg/ml),对 hERG 通道表现出抑制作用 (IC50: 1.89 μM)。
T72262 Antituberculosis agent-6

Antituberculosis agent-6 是一种有效的抗结核分枝杆菌 (antimycobacterial) 剂。Antituberculosis agent-6 对M. tuberculosis 显示出显著的抑制活性,MIC 为 3.49 μM。Antituberculosis agent-6 还对A. niger 表现出良好的抗真菌 (antifungal) 活性,MIC 为 62.50 μM。 Antituberculosis agent-6 表现出高胃肠道吸收。
T61665 Antibacterial agent 118

Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The minimum inhibitory concentration (MIC) values for Antibacterial agent 118 against these strains are 40.7 μM, 10.2 μM, 163.0 μM, 62.5 μM, and 62.5 μM, respectively. This compound holds potential for tuberculosis research [1].
T37880 OPC-167832

OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ...
T72263 Antituberculosis agent-8

Antituberculosis agent-8 是一种抗结核剂,对M. tuberculosis H37Rv 的 MIC 值为 3.53 μM (1.6 μg/mL)。Antituberculosis agent-8 对A. niger 也显示出良好的抗真菌 (antifungal) 活性,MIC 为 62.50 μM。
T60971 Antitubercular agent-14

Antitubercular agent-14 (Compound 1) 具有抗结核活性。Antitubercular agent-14 对结核分枝杆菌的 MIC 值为 0.3 μg/mL。
T61772 PknB-IN-1

PknB-IN-1 (Compound 2) is an inhibitor of protein kinase B (PknB) with a concentration causing 50% inhibition (IC50) of 14.4 μM. This compound demonstrates anti-mycobacterial activity by effectively suppressing the growth of M. tuberculosis H37Rv strain, with a minimum inhibitory concentration (MIC) of 6.2 μg/mL [1].
T36541 Nornidulin

Nornidulin is a depsidone originally isolated from A. nidulans that has antibacterial activity against M. tuberculosis and M. ranoe as well as antifungal activity against T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 2 μg/ml) and has larvicidal activity toward Artemia (LC50 = 1.7 μg/ml). Nornidulin has cytotoxic activity in MOLT-3 cells (IC50 = 35.7 μM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >116.4 μM).
T38073 Thiocarlide

Isoxyl

Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 &#181g/ml. [1] [2] At concentrations of 10 &#181M, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drug...
T37070 Pyridomycin

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).
T73032 MtInhA-IN-1

MtInhA-IN-1是一种口服活性的选择性结核分枝杆菌NADH依赖性烯酰基载体蛋白还原酶(MtInhA)抑制剂,IC50值为0.23 μM。对结核分枝杆菌H37Rv菌株,其MIC为0.4 μM。
T74771 Diaporthein B

Diaporthein B 是氧化程度极高的 pimarane 二萜之一。Diaporthein B 表现出抗结核分枝杆菌的活性,MIC 为 3.1 μg/mL。Diaporthein B 显示对 HCT 116 和 LoVo 结肠癌细胞的 IC50为 1.5-3 μM/L。

化合物

Dup-721
Cat.No: T38359
Synonym:
Target: Antibacterial
C-215
Cat.No: T8411
Synonym:
Target: Others
Norverapamil hydrochloride
Cat.No: T16339
Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米
Target: Calcium Channel, P-gp, Drug Metabolite
Q203
Cat.No: T5400
Synonym: IAP6,Telacebec
Target: Antibacterial, Antibiotic
GSK2556286
Cat.No: T9830
Synonym: GSK286
Target: Antibacterial
Mitonafide
Cat.No: T25817
Synonym: NSC-300288,米托萘胺,NSC300288,NSC 300288
Target: Antibacterial
TBAJ-587
Cat.No: T5997
Synonym:
Target: Antibacterial, Antibiotic
AX20017
Cat.No: T7312
Synonym:
Target: Others, Antibacterial
BM212
Cat.No: T7342
Synonym:
Target: Antibacterial
Sodium 4-aminosalicylate dihydrate
Cat.No: T0020
Synonym: 对氨基水杨酸钠二水合物,Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt
Target: Free radical scavengers, NF-κB, Antibacterial, Antibiotic
GSK572A
Cat.No: T27482
Synonym:
Target: Others
GSK2200150A
Cat.No: T4531
Synonym:
Target: Antibacterial
BM635
Cat.No: T10563
Synonym:
Target: Others
LCS3
Cat.No: T60446
Synonym:
Target: Apoptosis, Glutathione reductase
BM635 mesylate (1493762-74-5 free base)
Cat.No: T10563L2
Synonym: BM635 mesylate
Target: Others
BM635 hydrochloride (1493762-74-5 free base)
Cat.No: T10563L
Synonym: BM635 hydrochloride
Target: Others
Polyketide synthase 13-IN-3
Cat.No: T39693
Synonym:
Target:
Homo-BacPROTAC7
Cat.No: T75168
Synonym:
Target:
DprE1-IN-377790
Cat.No: T27206
Synonym:
Target:
LeuRS-IN-1 hydrochloride
Cat.No: T38773
Synonym:
Target:
A039
Cat.No: T29505
Synonym: A-039,A 039
Target:
Trichomonacid
Cat.No: T68809
Synonym:
Target:
CRS400393
Cat.No: T10887
Synonym:
Target: Antibacterial
ML338
Cat.No: T39109
Synonym: ML338
Target:
MtTMPK-IN-5
Cat.No: T61573
Synonym:
Target:
CB5255829
Cat.No: T69488
Synonym:
Target:
CB6513745
Cat.No: T71846
Synonym:
Target:
Antitubercular agent-22
Cat.No: T63755
Synonym:
Target:
MtTMPK-IN-6
Cat.No: T61781
Synonym:
Target:
Homo-BacPROTAC6
Cat.No: T75167
Synonym:
Target:
MmpL3-IN-1
Cat.No: T61303
Synonym:
Target:
Antitubercular agent-24
Cat.No: T61520
Synonym:
Target:
Antitubercular agent-23
Cat.No: T63525
Synonym:
Target:
α/β-Hydrolase-IN-1
Cat.No: T40317
Synonym:
Target:
Q-203 Ditosylate
Cat.No: T28480
Synonym: Q203,Q-203,Q 203
Target:
Capreomycin free base
Cat.No: T71449
Synonym:
Target:
Lariatin A
Cat.No: T38355
Synonym:
Target:
Antibacterial agent 96
Cat.No: T61170
Synonym:
Target:
WX-081
Cat.No: T63786
Synonym:
Target:
Antituberculosis agent-6
Cat.No: T72262
Synonym:
Target:
Antibacterial agent 118
Cat.No: T61665
Synonym:
Target:
OPC-167832
Cat.No: T37880
Synonym:
Target:
Antituberculosis agent-8
Cat.No: T72263
Synonym:
Target:
Antitubercular agent-14
Cat.No: T60971
Synonym:
Target:
PknB-IN-1
Cat.No: T61772
Synonym:
Target:
Nornidulin
Cat.No: T36541
Synonym:
Target:
Thiocarlide
Cat.No: T38073
Synonym: Isoxyl
Target:
Pyridomycin
Cat.No: T37070
Synonym:
Target:
MtInhA-IN-1
Cat.No: T73032
Synonym:
Target:
Diaporthein B
Cat.No: T74771
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T1426 Pyrazinamide

Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺

Antibacterial; Antibiotic; Autophagy; Fatty Acid Synthase Autophagy; Metabolism; Microbiology/Virology
Pyrazinamide (Pyrazinecarboxamide) 是一种口服抗结核类抗生素。它是一种前药,通过结核分枝杆菌pncA 基因编码的 PZase/烟酰胺酶转化为活性吡嗪酸形式。
TQ0184 Chebulinic acid

ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。
T4964 steviolbioside

CCRIS-6025,菊双糖甙,甜菊双糖苷

Others Others
Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用,对乳腺癌具有潜在的研究价值。
TN3674 Clauszoline M

Antifection Microbiology/Virology
Clauszoline M shows a significant anti-tuberculosis activity.
TN3422 Anisofolin A

Antifection Microbiology/Virology
Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis.
T38019 Nybomycin

Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively).
T69368 GKK1032B

GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis.
TN5404 (+)-Conocarpan

Conocarpan has antinociceptive effects. Conocarpan is quite active against S. aureus and B. subtilis with MIC of 6.25 micrograms/ml, it also shows activity against M. tuberculosis (MIC=15.6 ug/ml). Conocarpan shows considerable activity against epimastigo
T75676 Orotidine 5′-monophosphate trisodium

Orotidine 5'-monophosphate trisodium 是一种嘧啶核苷酸。Orotidine 5'-monophosphate trisodium 是通过从头合成途径合成的,用于在大量微生物中合成 DNA,包括 M. tuberculosis、S. cerevisiae、S. typhimurium 和 P. falciparum 等等。乳清酸磷酸核糖基转移酶 (OPRT) 以磷酸核糖焦磷酸 (PRPP) 和乳清酸 (OA) 作为底物催化合成 Orotidine 5'-monophosphate trisodium[1]
T36815 Chevalone C

Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.
T38330 Collinin

Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Pyrazinamide
Cat.No: T1426
Synonym: Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺
Target: Antibacterial, Antibiotic, Autophagy, Fatty Acid Synthase
Chebulinic acid
Cat.No: TQ0184
Synonym:
Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad
steviolbioside
Cat.No: T4964
Synonym: CCRIS-6025,菊双糖甙,甜菊双糖苷
Target: Others
Clauszoline M
Cat.No: TN3674
Synonym:
Target: Antifection
Anisofolin A
Cat.No: TN3422
Synonym:
Target: Antifection
Nybomycin
Cat.No: T38019
Synonym:
Target:
GKK1032B
Cat.No: T69368
Synonym:
Target:
(+)-Conocarpan
Cat.No: TN5404
Synonym:
Target:
Orotidine 5′-monophosphate trisodium
Cat.No: T75676
Synonym:
Target:
Chevalone C
Cat.No: T36815
Synonym:
Target:
Collinin
Cat.No: T38330
Synonym:
Target:
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